Research Paper
Epigenetic Age Acceleration Predicts Cardiovascular Mortality in a South Asian Cohort
Mehra A, Kapoor R, Iyer P, et al. · Journal of Longevity Research · 2024
Abstract
In a prospective cohort of 2,847 South Asian adults followed for 7 years, we found that DunedinPACE-measured epigenetic age acceleration was a stronger predictor of cardiovascular mortality (HR 2.31, 95% CI 1.84–2.89) than chronological age, BMI, or LDL-C.
Methods
We enrolled 2,847 adults aged 35–75 across five Indian cities. Baseline DunedinPACE was measured from whole-blood DNA methylation. Participants were followed for 7 years with biannual cardiovascular event adjudication.
Key findings
- Each 0.1-unit increase in pace of aging conferred a 23% increase in CV mortality
- Effect persisted after adjusting for traditional risk factors
- Strongest predictive value in the 45–60 age band