Epigenetic Age Acceleration Predicts Cardiovascular Mortality in a South Asian Cohort
In a prospective cohort of 2,847 South Asian adults followed for 7 years, we found that DunedinPACE-measured epigenetic age acceleration was a stronger predictor of cardiovascular mortality (HR 2.31, 95% CI 1.84–2.89) than chronological age, BMI, or LDL-C.
Microbiome Diversity and Metabolic Health: A 1,000-Patient Cross-Sectional Study
Shotgun metagenomic analysis of 1,047 Indian adults reveals that microbial diversity (Shannon index) correlates inversely with HOMA-IR (r = -0.42, p < 0.001) and predicts metabolic syndrome incidence over 3-year follow-up.
Rapamycin Tolerability in a Longevity Cohort: Real-World Data from 218 Patients
Weekly intermittent rapamycin (6mg) was well-tolerated in 218 adults over 24 months, with no serious adverse events. Stomatitis (12%) and transient lipid elevation (8%) were the most common findings.
Continuous Glucose Monitoring in Non-Diabetic Adults: Variability as a Longevity Biomarker
In 412 non-diabetic adults wearing CGM for 14 days, post-prandial glucose variability (CV) above 36% was associated with elevated inflammatory markers and reduced HRV, independent of HbA1c.