Research Paper
Microbiome Diversity and Metabolic Health: A 1,000-Patient Cross-Sectional Study
Iyer P, Subramanian K, Rao K, et al. · Cell Host & Microbe Letters · 2024
Abstract
Shotgun metagenomic analysis of 1,047 Indian adults reveals that microbial diversity (Shannon index) correlates inversely with HOMA-IR (r = -0.42, p < 0.001) and predicts metabolic syndrome incidence over 3-year follow-up.
Background
The gut microbiome's role in metabolic health is well-established in Western cohorts but poorly characterised in South Asian populations.
Findings
We identified three distinct enterotypes. Enterotype 2, dominated by Prevotella copri, was associated with significantly improved insulin sensitivity even at higher BMIs.